Innovative Processing Technologies for Foods with Bioactive Compounds by Jorge J. Moreno

Author:Jorge J. Moreno
Language: eng
Format: epub
Publisher: CRC Press

FIGURE 7.1 Representative scheme of multilayer nanocapsules after LbL deposition onto the different colloidal templates.

Therefore, the LbL technique offers a promising way to improve the stability of the actual delivery systems. Nevertheless, the optimization of this technique depends on the preparation conditions (bioactive compound concentration, pH, ionic strength, temperature), the choice of appropriate polyelectrolytes and their combination, as well as the knowledge of the physicochemical principles involved. Also, multilayer nanocapsules construction implies long times, with the assembly of a single layer taking typically a few minutes, depending on the nature of the polyelectrolytes (Costa et al. 2015) and the formation of stable multilayer nanocapsules requires meticulous control of the system composition and preparation in order to avoid droplet aggregation (Guzey and McClements 2006). Another limitation is the fact that LbL method is based on electrostatic interactions, and they can be disrupted by changes in pH and ionic strength (McClements 2010, McClements and Li 2010). Also, depending on the template used, the removal of the core template could be required, leaving traces of solvent (Guzey and McClements 2006, McClements et al. 2007, Li et al. 2010, McClements 2010, McClements and Li 2010, Szczepanowicz et al. 2015). Despite the method for producing multilayer nanocapsules being simple, additional processing steps are frequently needed over the nanocapsule formation and diluted multilayer nanocapsules are typically obtained (McClements et al. 2007).

Although LbL devices did not receive significant attention from a scale-up perspective, efforts in developing devices able to produce multilayer nanocapsules in an automated way have been reported (Priest et al. 2008, Kantak et al. 2011, Costa et al. 2015).

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